Protective effects of retinoid x receptors on retina pigment epithelium cells
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- 作者：Victoria Belé ; n Ayala-Peñ ; a ; Fiorella Pilotti ; Yanel Volonté ; Nora P. Rotstein ; Luis E. Politi ; Olga Lorena German ; olgerman@criba.edu.ar" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMD ; age-related macular degeneration ; RPE ; retina pigment epithelium cells ; ROS ; reactive oxygen species ; PUFA ; polyunsaturated fatty acids ; DHA ; docosahexaenoic acid ; RXRs ; retinoid x receptors ; PPAR ; peroxisome proliferator-activated receptor ; LXR ; liver X receptor ; RAR ; Retinoic acid receptor ; Bclxl ; B-cell lymphoma-extra large ; Bcl-2 ; B-cell lymphoma-2 ; Bax ; Bcl-2-associated X protein ; NFκB ; nuclear factor kB ; RA ; retinoic acid ; H2O2 ; hydrogen peroxide ; DMEM ; Dulbecco's modified Eagle's med
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1863
- 期：6
- 页码：1134-1145
- 全文大小：2799 K
文摘
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Pan-RXR agonists protected RPE cells from oxidative stress induced by H2O2.
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HX630, a RXR agonist, prevented apoptosis by regulating Bclxl, PPARγ and Bax mRNA levels.
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HX630 decreased nuclear translocation of p65NFκB and caspase-3 activation.
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Pan-RXR agonists acted through activation of RXR/PPARγ or, less probably, RXR/RXR.
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RXR/RAR was not involved in pan-RXR agonist protection on RPE cells.