Mechanism of β-actin mRNA Recognition by ZBP1

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• 作者：Giuseppe Nicastro¹ ; ¹⁰ ; Adela M. Candel² ; ¹⁰ ; Michael Uhl³ ; Alain Oregioni⁴ ; David Hollingworth⁵ ; Rolf Backofen³ ; ⁶ ; Stephen R. Martin⁷ ; Andres Ramos⁸ ; ⁹ ; ¹¹ ; ^{a.ramos@ucl.ac.uk}
• 关键词：protein-RNA interactions ; NMR ; binding mechanism ; neuronal mRNA granules ; neuronal development ; mRNA local translation ; ZBP1 ; IMP1
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：31 January 2017
• 年：2017
• 卷：18
• 期：5
• 页码：1187-1199
• 全文大小：3158 K
• 卷排序：18

文摘

The dynamic groove of ZBP1’s KH4 domain allows recognition of a G-rich RNA sequence ZBP1’s KH3 and KH4 domains bind their target RNA sequences with similar affinities RNA looping drives the ZBP1-β-actin interaction The protein, rather than the RNA, concentration regulates ZBP1-β-actin mRNA binding