Apoptosis in human myelodysplastic syndrome CD34+ cells is modulated by the upregulation of TLRs and histone H4 acetylation via a β-arrestin 1 dependent mechanism
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- 作者：Qing Zenga ; 1 ; Jing Shub ; 1 ; Qi Huc ; Shao-Hong Zhoua ; Yi-Ming Qiana ; Ming-Hui Hua ; Ling-Yan Hua ; Yu-Guang Wanga ; Yong-Ming Zhoua ; Yongmingz@sohu.com" class="auth_mail" title="E-mail the corresponding author ; Jia-Hui Luc ; Lujiahui73@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Myelodysplastic syndromes (MDS) ; Apoptosis ; Histone acetylation ; Toll-like receptor ; β-arrestin 1
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：340
- 期：1
- 页码：22-31
- 全文大小：2165 K
文摘
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TLR2 is upregulated in lower-risk MDS patients.
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TLR2 expression and H4 acetylation correlated with increased CD34+ cell apoptosis.
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TLR2-induced apoptosis was mediated by β-arr1 upregulation in normal CD34+ cells.
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β-arr1 mediated recruitment of p300 lead to increased histone H4 acetylation levels.