Inter- and intra-cellular mechanism of NF-kB-dependent survival advantage and clonal expansion of radio-resistant cancer cells

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• 作者：Hui Yu^a ; ^b ; Natarajan Aravindan^c ; Ji Xu^d ; Mohan Natarajan^a ; ^{natarajan@uthscsa.edu}
• 关键词：Radiotherapy ; Feedback signaling ; Breast cancer ; Tumor recurrence ; Non-targeted effect
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：31
• 期：Complete
• 页码：105-111
• 全文大小：767 K
• 卷排序：31

文摘

Understanding the mechanism of tumor recurrence after radiotherapy is important in achieving disease-free survival in cancer patients. Radiation-triggered nuclear factor kappa B maintains a self-sustenance mechanism through a positive feed-back cycle. Persistent activation of NF-kB imparts survival advantage to the cancer cells that survive treatment through selective downstream determinants. Thus favorably selected cancer cells undergo clonal expansion resulting in tumor promotion/progression at the treatment site. Molecular targeting of radiation-induced NF-kB feed-back axis could prevent tumor recurrence and improve the quality of life of cancer patients.