OMS-2 materials with different microstructures were synthesized. The effect of reducing agent on OMS-2 structure was studied. The best catalyst (B-OMS-2) could convert 100% o-xylene into CO2 at 190 °C. B-OMS-2 presented a loose structure and high bulk oxygen vacancy. B-OMS-2 exhibited good low-temperature reducibility and high reoxidation ability.