Human carbonyl reductase 1 as efficient catalyst for the reduction of glutathionylated aldehydes derived from lipid peroxidation
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- 作者：Rossella Rotondoa ; 1 ; Roberta Moschinia ; 1 ; Giovanni Renzoneb ; 1 ; Tiziano Tuccinardic ; Francesco Balestria ; Mario Cappielloa ; Andrea Scalonib ; Umberto Muraa ; Antonella Del-Corsoa ; antonella.delcorso@unipi.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：GSDHN ; 3-glutathionyl-1 ; 4-dihydroxynonane ; GSHNE ; 3-glutathionyl-4-hydroxynonal ; GSHNA-lactone ; 3-glutathionyl-4-hydroxynonanoic-δ-lactone ; HHE ; 4-hydroxy-2-hexenal ; HNE ; 4-hydroxy-2-nonenal ; ONE ; 4-oxo-trans-2-nonenal ; 9 ; 10-PQ ; 9 ; 10-phenanthrenquinone ; BSA ; bovine serum albumin ; CBR1 ; carbonyl reductase 1 ; EIC ; extracted ion chromatograms ; DMSO ; dimethyl sulfoxide ; DTT ; D ; L-dithiotreitol ; hCBR1 ; human recombinant carbonyl reductase 1 ; ΔRT ; interval of retention time ; IPTG ; isopropyl-β-D-thiogal
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：323-332
- 全文大小：1712 K
文摘
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CBR1 efficiently catalyzes the reduction of glutathionylated aldehydes.
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10">A disproportion reaction of GSHNE catalyzed by CBR1 occurs.
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15">The generation of GSDHN makes CBR1 involved in the inflammatory signalling cascade.