Production of polyketides with anthelmintic activity by the fungus Talaromyces wortmannii using one strain-many compounds (OSMAC) method

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• 作者：Wen-Cai Liu^a ; Fan Yang^a ; Ran Zhang^a ; Xuan Shi^a ; Xin-Hua Lu^b ; Yu-Shi Luan^a ; Zhi-Long Xiu^a ; Yue-Sheng Dong ; Ph. D^a ; ^{yshdong@dlut.edu.cn} (Associate Professor)
• 关键词：Talaromyces wortmannii ; Polyketides ; OSMAC ; Absolute configuration ; Anthelmintic activity ; NADH-fumarate reductase inhibitor
• 刊名：Phytochemistry Letters
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：18
• 期：Complete
• 页码：157-161
• 全文大小：946 K
• 卷排序：18

文摘

OSMAC strategy could increase the kind of wortmannilactones. Three new wortmannilactones, wortmannilactones I1-I3, were isolated from medium of Talaromyces wortmannii. Their structures were assigned by IR, HRESIMS, NMR and ECD. These new wortmannilactones exhibit selective inhibitory activity against NADH-fumarate reductase.