Acellular dermal matrix loading with bFGF achieves similar acceleration of bone regeneration to BMP-2 via differential effects on recruitment, proliferation and sustained osteodifferentiation of mesenchymal stem cells
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- 作者：Mi Du ; Ting Zhu ; Xiaoqi Duan ; Shaohua Ge ; Ning Li ; Qinfeng Sun ; sunqinfeng@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Pishan Yang ; yangps@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acellular dermal matrix ; Basic fibroblast growth factor ; Bone morphogenetic protein-2 ; Guided bone regeneration ; Guided tissue regeneration
- 刊名：Materials Science & Engineering C
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：70
- 期：part_P1
- 页码：62-70
- 全文大小：1690 K
文摘
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An improved barrier membrane used in the field of bone tissue engineering was proposed, which is acellular dermal matrix (ADM) loaded with growth factors.
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It is generally agreed that BMP-2 and -7 provide the greatest bone regeneration potentials, however, we found that ADM loading with bFGF could guide similar bone regeneration to BMP-2.
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Compared with BMP-2, bFGF could more effectively recruit MSCs and moreover, BMMSCs pretreated by bFGF showed out stronger proliferation at 1-5 days and osteogenic differentiation potentials at 14 days.
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