Peptidic Biomaterials: From Self-Assembling to Regenerative Medicine

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• 作者：Raffaele Pugliese¹ ; Fabrizio Gelain¹ ; ² ; ^{f.gelain@css-mendel.it}
• 关键词：biomimetic scaffold ; co-assembling peptide ; functional motif ; regenerative medicine ; self-assembling peptide
• 刊名：Trends in Biotechnology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：35
• 期：2
• 页码：145-158
• 全文大小：4406 K
• 卷排序：35

文摘

Peptidic biomaterials represent a particularly exciting topic in regenerative medicine. Peptidic scaffolds can be specifically designed for biomimetic customization for targeted therapy. The field is at a pivotal point where preclinical research is being translated into clinics, so it is crucial to understand the theory and describe the status of this rapidly developing technology. In this review, we highlight major advantages and current limitations of self-assembling peptide-based biomaterials, and we discuss the most widely used classes of assembling peptides, describing recent and promising approaches in tissue engineering, drug delivery, and clinics. We also suggest design strategies and hurdles that still need to be overcome to fully exploit their therapeutic potential.