Caenorhabditis elegans chronically exposed to a Mn/Zn ethylene-bis-dithiocarbamate fungicide show mitochondrial Complex I inhibition and increased reactive oxygen species
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- 作者：Denise C. Baileya ; dbailey@king.edu" class="auth_mail" title="E-mail the corresponding author ; Callie E. Todta ; ctodt@king.edu" class="auth_mail" title="E-mail the corresponding author ; Sarah E. Orfielda ; seorfield@student.king.edu" class="auth_mail" title="E-mail the corresponding author ; Rachel D. Denneya ; radonaldson@student.king.edu" class="auth_mail" title="E-mail the corresponding author ; Isaac B. Snappa ; snapp@musc.edu" class="auth_mail" title="E-mail the corresponding author ; Rekek Neggaa ; rnegga@utk.edu" class="auth_mail" title="E-mail the corresponding author ; Kara M. Montgomerya ; kmontgomery@student.king.edu" class="auth_mail" title="E-mail the corresponding author ; Andrew C. Baileya ; abailey@student.king.edu" class="auth_mail" title="E-mail the corresponding author ; Aireal S. Pressleya ; adpressley@outlook.com" class="auth_mail" title="E-mail the corresponding author ; Wendy L. Traynorb ; dbailey@king.edu" class="auth_mail" title="E-mail the corresponding author ; Vanessa A. Fitsanakisa ; dbailey@king.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：PD ; Parkinson&rsquo ; s disease ; MZ ; Manzate ; Mn/Zn-EBDC ; Mn/Zn ethylene-bis-dithiocarbamate ; C. elegans ; Caenorhabditis elegans ; ROS ; Reactive oxygen species ; E. coil ; Escherichia coli ; CGC ; Caenorhabditis Genetics Center ; GFP ; Green fluorescent protein ; L2 ; Second larval stage ; NGM ; Nematode growth media ; EDTA ; Ethylene diamine tetraacetic acid ; EGTA ; Ethylene glycol tetraacetic acid ; NBT ; Nitroblue tetrazolium ; DAB ; 3 ; 3&prime ; -Diaminobenzidine ; TMRE ; Tetramethylrhodamine ethyl ester ; DMSO ; Dime
- 刊名：Neurotoxicology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：56
- 期：Complete
- 页码：170-179
- 全文大小：1665 K
文摘
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C. elegans treated with the fungicide manzate show reduced mitochondrial respiration.
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The decreased respiration can be attributed to Complex I inhibition.
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Increased hydrogen peroxide, but not other reactive oxygen species, was detected.
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Increased glutathione-S-transferase levels were also observed.
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Mitochondrial inhibition and oxidative stress may be mechanisms of manzate toxicity.