Anti-apoptotic treatment in mouse models of age-related hearing loss

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• 作者：Fengchan Han^a ; ^b ; ^{hanfengchan@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Oumei Wang^a ; ^b ; Quanxiang Cai^a ; ^b
• 关键词：Age-related hearing loss ; Mouse model ; Apoptosis ; Oxidative stress
• 刊名：Journal of Otology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：11
• 期：1
• 页码：7-12
• 全文大小：308 K

文摘

Age-related hearing loss (AHL), or presbycusis, is the most common neurodegenerative disorder and top communication deficit of the aged population. Genetic predisposition is one of the major factors in the development of AHL. Generally, AHL is associated with an age-dependent loss of sensory hair cells, spiral ganglion neurons and stria vascularis cells in the inner ear. Although the mechanisms leading to genetic hearing loss are not completely understood, caspase-family proteases function as important signals in the inner ear pathology. It is now accepted that mouse models are the best tools to study the mechanism of genetic hearing loss or AHL. Here, we provide a brief review of recent studies on hearing improvement in mouse models of AHL by anti-apoptotic treatment.