Lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNFα) blunt the response of Neuropeptide Y/Agouti-related peptide (NPY/AgRP) glucose inhibited (GI) neurons to decreased glucose
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- 作者：Lihong Haoa ; b ; Zhenyu Shenga ; Joseph Potiana ; Adam Deaka ; Christine Rohowsky-Kochana ; Vanessa H. Routha ; routhvh@njms.rutgers.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：3V ; 3rd cerebral ventricle ; AgRP ; agouti-related peptide ; ARC ; arcuate nucleus ; Cpd C ; compound C ; GI ; glucose-inhibited ; INFγ ; interferon gamma ; IL-1 ; interleukin-1 ; IL-6 ; interleukin-6 ; IR ; input resistance ; LPS ; lipopolysaccharide ; ME ; median eminence ; NPY ; neuropeptide Y ; PBS ; phosphate buffered saline ; PFA ; paraformaldehyde ; TBST ; Tris-Buffered Saline with 0.1% Tween 20 ; TNFα ; tumor necrosis factor alpha ; TTX ; tetrodotoxin ; VMN ; ventromedial nucleus
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：1648
- 期：part_PA
- 页码：181-192
- 全文大小：3210 K
文摘
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LPS blunted fasting induced activation of NPY/AgRP-GI neurons by decreased glucose;
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TNFα blocked the activation of NPY/AgRP-GI neurons by decreased glucose;
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Glucose sensing by NPY/AgRP-GI neurons is different than published for VMH-GI neurons.