Biased signaling initiated by agouti-related peptide through human melanocortin-3 and -4 receptors
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- 作者：Zhao Yang ; Ya-Xiong Tao ; taoyaxi@auburn.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Melanocortin-3 receptor ; Melanocortin-4 receptor ; Agouti-related peptide ; Biased signaling
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1862
- 期：9
- 页码：1485-1494
- 全文大小：1559 K
文摘
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AgRP acted as a biased agonist in human MC3R, decreasing cAMP level but stimulating ERK1/2 activation.
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AgRP stimulated ERK1/2 phosphorylation through MC3R and MC4R by different mechanisms.
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Both NDP-MSH and AgRP treatment induced significant AKT phosphorylation in MC4R-expressing GT1-7 cells.
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NDP-MSH, but not AgRP, inhibited AMPK activity in MC3R-transfacted HEK293T cells.