Differences in the recruitment of DNA repair proteins at subtelomeric and interstitial I-SceI endonuclease-induced DNA double-strand breaks

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• 作者：Bá ; rbara Alcaraz Silva ; Trevor J. Jones ; John P. Murnane ; ^{John.Murnane@ucsf.edu}
• 关键词：DNA repair ; Double-strand breaks ; Telomere
• 刊名：DNA Repair
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：Complete
• 页码：1-8
• 全文大小：1330 K
• 卷排序：49

文摘

Nonhomologous end-joining protein Ku70 is similar at interstitial and subtelomeric DSBs. Repair proteins RAD51, BRCA1 and CtIP are greatly increased at subtelomeric DSBs. ATM is reduced at subtelomeric DSBs compared to interstitial DSBs. ATR is increased at subtelomeric DSBs compared to interstitial DSBs. DSBs near telomeres are more likely to be inappropriately processed.