Nuclear Dynamics of Heterochromatin Repair

详细信息    查看全文

• 作者：Nuno Amaral¹ ; ² ; Taehyun Ryu¹ ; ² ; Xiao Li¹ ; Irene Chiolo¹ ; ^{chiolo@usc.edu}
• 刊名：Trends in Genetics
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：33
• 期：2
• 页码：86-100
• 全文大小：1877 K
• 卷排序：33

文摘

Repairing double-strand breaks (DSBs) is particularly challenging in pericentromeric heterochromatin, where the abundance of repeated sequences exacerbates the risk of ectopic recombination and chromosome rearrangements. Recent studies in Drosophila cells revealed that faithful homologous recombination (HR) repair of heterochromatic DSBs relies on the relocalization of DSBs to the nuclear periphery before Rad51 recruitment. We summarize here the exciting progress in understanding this pathway, including conserved responses in mammalian cells and surprising similarities with mechanisms in yeast that deal with DSBs in distinct sites that are difficult to repair, including other repeated sequences. We will also point out some of the most important open questions in the field and emerging evidence suggesting that deregulating these pathways might have dramatic consequences for human health.