A comprehensive review of intake estimates of di-isononyl phthalate (DINP) based on indirect exposure models and urinary biomonitoring data

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• 作者：Kevin M. Kransler ; ^{kevin.kransler@exxonmobil.com} ; Ammie N. Bachman ^{ammie.n.bachman@exxonmobil.com} ; Richard H. McKee ^{richard.h.mckee@exxonmobil.com}
• 关键词：ADI ; acceptable daily intake ; CE ; creatinine excretion rate ; CERHR ; Center for the Evaluation of Risks to Human Reproduction ; CPSIA ; Consumer Product Safety Improvement Act of 2008 ; DINP ; diisononyl phthalate ; FUE ; fractional urinary excretion ; MINP ; mono
• 刊名：Regulatory Toxicology and Pharmacology
• 出版年：2012
• 出版时间：March, 2012
• 年：2012
• 卷：62
• 期：2
• 页码：248-256
• 全文大小：231 K

文摘

Di-isononyl phthalate (DINP) is a high molecular weight general purpose plasticizer used principally in the manufacture of flexible polyvinyl chloride (PVC) articles. DINP metabolites can be measured in biological media such as blood and urine. However, measurement of a substance in the blood or urine does not by itself mean that the chemical causes or is associated with adverse health outcomes. This is particularly pertinent given the advances in modern analytical techniques whereby ever diminishing trace amounts of substances can be detected. Therefore, it is a scientific necessity that risk assessors understand the relationship of biomonitoring data to estimation of exposure so that appropriate comparisons can be made to the no observed adverse effects levels (NOAELs) or other points of departure from toxicological studies in animals. In this paper, estimates of daily DINP intake are calculated for various population segments based on urinary biomonitoring data and are compared to estimates of exposure based on indirect methods and to health-based exposure guidance values. In general, intake estimates converge on a mean of 1-2 ¦Ìg/kg/day regardless of source of exposure or population cluster; a value 2-orders of magnitude lower than health-based exposure guidance values, ranging from 120 to 290 ¦Ìg/kg/day, which have been established by regulatory authorities and other authoritative bodies as representing acceptable levels.