Influence of MRP1 G1666A and GSTP1 Ile105Val genetic variants on the urinary and blood arsenic levels of Turkish smelter workers
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- 作者：Dilek Kaya-Akyü ; zlü ; Zeliha Kayaaltı ; kayaalti@ankara.edu.tr" class="auth_mail" title="E-mail the corresponding author ; zkayaalti@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Tü ; lin Sö ; ylemezoğlu
- 关键词：Human multidrug resistance protein 1 (MRP1) ; Glutathione S-transferase P1 (GSTP1) ; Arsenic ; Blood ; Urine ; Smelter workers
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：43
- 期：Complete
- 页码：68-73
- 全文大小：641 K
文摘
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Individuals with MRP1A−/GSTP1Val− had significantly higher urinary arsenic levels.
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Individuals with the MRP1A−/GSTP1Val− had lower blood arsenic levels.
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Individuals with MRP1A−/GSTP1Val− might be advantageous for being protected from arsenic toxicity.
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Genetic variants in MRP1 G1666A seemed to affect individual susceptibility to arsenic toxicity.