Cyanidin-3-O-glucoside ameliorates palmitate-induced insulin resistance by modulating IRS-1 phosphorylation and release of endothelial derived vasoactive factors

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• 作者：Deborah Fratantonio^a ; Francesco Cimino^a ; ^{fcimino@unime.it} ; Maria Sofia Molonia^a ; Daniela Ferrari^a ; Antonella Saija^a ; Fabio Virgili^b ; Antonio Speciale^a
• 关键词：C3G ; cyanidin-3-O-glucoside ; HUVECs ; human umbilical vein endothelial cells ; PA ; palmitic acid ; TNF-α ; Tumor necrosis factor-alpha ; SRB ; Sulforhodamine B ; ET-1 ; endothelin-1 ; PAI-1 ; plasminogen activator inhibitor-1 ; NO ; nitric oxide
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1862
• 期：3
• 页码：351-357
• 全文大小：712 K
• 卷排序：1862

文摘

C3G counters FFA-induced dysregulation of insulin-modulated Akt/eNOS axis. C3G restores NO availability altered by FFA. C3G ameliorates insulin resistance, induced by FFA, through Nrf2 activation.