Scaling laws of coronary circulation in health and disease

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• 作者：Yunlong Huo^a ; ^b ; ^c ; ^{yhuo@pku.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Ghassan S. Kassab^d ; ^{gkassab@calmi2.org" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Coronary vasculature ; Coronary circulation ; Scaling power law ; Fractal dimension
• 刊名：Journal of Biomechanics
• 出版年：2016
• 出版时间：16 August 2016
• 年：2016
• 卷：49
• 期：12
• 页码：2531-2539
• 全文大小：1256 K

文摘

The heterogeneity and complexity of coronary vasculature (structure) and myocardial flow (function) have fractal-like characteristics and can be described by scaling laws with remarkable simplicity. In contrast with allometric (interspecific) scaling law, intraspecific scaling laws describe the design rules of vascular trees within a species. This paper provides an overview of intraspecific scaling laws of vascular trees and the physiological and clinical implications thereof. The significance and shortcomings of these scaling laws are discussed in relation to diffuse coronary artery disease, Glagov’s positive remodeling in early stages of coronary atherosclerosis, treatment guidelines of complex bifurcation lesions, and for estimation of outlet resistance values for computation of blood flow in epicardial coronary arteries. Finally, we summarize the highlights of scaling relations and suggest some future directions.