Non-invasive evaluation of atopic dermatitis based on redox status using in vivo dynamic nuclear polarization magnetic resonance imaging

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• 作者：Hinako Eto^a ; Gaku Tsuji^b ; ^c ; Takahito Chiba^b ; Masutaka Furue^b ; ^c ; Fuminori Hyodo^a ; ^{hyodof@redoxnavi.med.kyushu-u.ac.jp}
• 关键词：AD ; atopic dermatitis ; Th ; T helper ; ROS ; reactive oxygen species ; DNP ; dynamic nuclear polarization ; MRI ; magnetic resonance imaging ; EPR ; electron paramagnetic resonance ; SDS ; sodium dodecyl sulfate ; HE ; hematoxylin and eosin ; TB ; toluidine blue
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：209-215
• 全文大小：1029 K
• 卷排序：103

文摘

We describe a method for redox imaging of dermis using dynamic nuclear polarization magnetic resonance imaging. In vivo DNP-MRI clearly visualized nitroxyl radical distribution in dermis. Early redox alteration in dermis of NC/Nga mice was observed noninvasively.