The DNA damage response of C. elegans affected by gravity sensing and radiosensitivity during the Shenzhou-8 spaceflight

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• 作者：Ying Gao^a ; ^c ; Dan Xu^b ; Lei Zhao^b ; Yeqing Sun^b ; ^{yqsun@dlmu.edu.cn}
• 关键词：Microgravity ; Space radiation ; Transcriptional response ; DNA damage response
• 刊名：Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：795
• 期：Complete
• 页码：15-26
• 全文大小：3917 K
• 卷排序：795

文摘

Extrinsic condition and intrinsic sensitivity both affect responses to spaceflight. Protein phosphorylation/dephosphorylation is sensitive to μg and space radiation. Microgravity affects transcription depending on dystrophin gene dys-1 in C.elegans. Loss-function of apoptotic gene ced-1 leads protective responses to space radiation.