Intermittent hypoxia confers pro-metastatic gene expression selectively through NF-κB in inflammatory breast cancer cells

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• 作者：Katrin Gutsche^a ; ^b ; ^c ; Elisa B. Randi^a ; ^b ; Volker Blank^d ; Daniel Fink^c ; Roland H. Wenger^a ; ^b ; Cornelia Leo^e ; ¹ ; ^{cornelia.leo@ksb.ch} ; Carsten C. Scholz^a ; ¹ ; ^{carsten.scholz@uzh.ch}
• 关键词：ADAM19 ; a disintegrin and metalloproteinase 19 ; AP-1 ; activator protein-1 ; ARE ; antioxidant response element ; BSP ; bisulfite sequencing PCR ; CA9 ; carbonic anhydrase IX ; CIH ; chronic intermittent hypoxia ; COX-2 ; cyclooxygenase-2 ; DCF ; 2' ; 7'-dichlorofluorescein ; DMF ; dimethyl fumarate ; ECM ; extracellular matrix ; ER ; estrogen receptor ; HIF ; hypoxia-inducible factor ; HO-1 ; heme oxygenase 1 ; IBC ; inflammatory breast cancer ; IH ; intermittent hypoxia ; IκBα ; inhibitor of NF-κB α ; IL1A ; interleukin-1α ; I
• 刊名：Free Radical Biology and Medicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：101
• 期：Complete
• 页码：129-142
• 全文大小：1748 K
• 卷排序：101

文摘

Intermittent hypoxia (IH) increases pro-metastatic gene expression in IBC cells. ROS activates NF-κB, Nrf2 and c-Jun in IBC cells. IH-dependent gene regulation depends on NF-κB but not on other ROS-induced pathways. IH is proposed as an important regulator of IBC aggressiveness.