MnTE-2-PyP modulates thiol oxidation in a hydrogen peroxide-mediated manner in a human prostate cancer cell

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• 作者：Qiang Tong^a ; ^b ; Yuxiang Zhu^a ; Joseph W. Galaske^a ; Elizabeth A. Kosmacek^a ; Arpita Chatterjee^a ; Bryan C. Dickinson^c ; Rebecca E. Oberley-Deegan^a ; ^{becky.deegan@unmc.edu}
• 关键词：PAI-1 ; plasminogen activator inhibitor-1 ; ROS ; reactive oxygen species ; HRE ; hypoxia-response element ; SOD1 ; superoxide dismutase 1 ; HIF-1 ; hypoxia-inducible factor-1 ; CREB ; cAMP response element-binding protein ; ChIP ; chromatin immunoprecipitation ; ARNT ; aryl hydrocarbon receptor nuclear translocator ; CAT ; catalase ; NucPE1 ; nuclear peroxy emerald 1
• 刊名：Free Radical Biology and Medicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：101
• 期：Complete
• 页码：32-43
• 全文大小：1529 K
• 卷排序：101

文摘

MnTE-2-PyP treatment mimics the activity of Cu/ZnSOD overexpression. MnTE-2-PyP treatment alone produces hydrogen peroxide, specifically in the nucleus. MnTE-2-PyP oxidizes protein thiols and this can be reversed with catalase overexpression. This study is crucial in determining how MnTE-2-PyP regulates redox signaling in cancer cells.