Modifiable chemically crosslinked poli(¦Ê-carrageenan) particles

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• 作者：Selin Sagbas^a ; Sultan Butun^a ; Nurettin Sahiner^a ; ^b ; ^{sahiner71@gmail.com}
• 关键词：¦Ê-Carrageenan microgels ; Magnetic particles ; Modifiable carrageenan particles ; Drug delivery system
• 刊名：Carbohydrate Polymers
• 出版年：2012
• 出版时间：1 March, 2012
• 年：2012
• 卷：87
• 期：4
• 页码：2718-2724
• 全文大小：961 K

文摘

Micron size ¦Ê-carrageenan hydrogel particles, p(CRN) from linear ¦Ê-carrageenan, were prepared via microemulsion polymerization using divinyl sulfone (DVS) as chemical crosslinker in a sodium bis(2-ethylhexyl) sulfosuccinate (AOT) reverse miceller system. Magnetic field responsive (m-p(CRN)) composite particles were also synthesized by encapsulating magnetic ferrite (Fe₃O₄) nanoparticles together with linear ¦Ê-carrageenan within the AOT reverse micelle before the crosslinking reaction. The synthesized bare p(CRN) particles were further modified to produce positive charges on the particles (q-p(CRN)) by a quaternization reaction with an 3-chloro-2-hydroxypropyl trimethyl ammonium chloride aqueous solution. Scanning electron microscopy (SEM), dynamic light scattering (DLS), zeta potential measurements and FT-IR analysis confirmed that particle sizes and charges were altered by chemical modification. Furthermore, a model drug, phenylephrine HCl was used for in vitro drug delivery studies to compare the effectiveness of modification of p(CRN) microgels by comparing bare p(CRN), m-p(CRN) and q-p(CRN) particles drug release capabilities in phosphate buffer solution (PBS) at pH 7.4.