Aldehyde-functionalized dendritic mesoporous silica nanoparticles as potential nanocarriers for pH-responsive protein drug delivery

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• 作者：Zhengfang Tian^a ; ¹ ; Yi Xu^b ; ¹ ; Yufang Zhu^a ; ^c ; ^{zjf2412@163.com}
• 关键词：Mesoporous silica ; Aldehyde functionalization ; Drug delivery ; Controlled release
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：452-459
• 全文大小：1496 K
• 卷排序：71

文摘

A potential pH-responsive protein drug delivery system was developed based on mesoporous silica nanoparticles (DMSNs-CHO). DMSNs-CHO nanoparticles had no cytotoxicity and could be efficiently taken up by cells. Protein drugs could release from DMSNs-CHO nanoparticles triggered by acidic environment.