Small molecules preventing GAPDH aggregation are therapeutically applicable in cell and rat models of oxidative stress
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- 作者：Vladimir F. Lazareva ; vl.lazarev@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Alina D. Nikotinaa ; Pavel I. Semenyukb ; Diana B. Evstafyevab ; Elena R. Mikhaylovaa ; Vladimir I. Muronetzb ; Maxim A. Shevtsova ; Anastasia V. Tolkachevaa ; Anatoly V. Dobrodumovc ; Alexey L. Shavardad ; Irina V. Guzhovaa ; Boris A. Margulisa
- 关键词：CSF ; cerebrospinal fluid ; DARTS ; drug affinity responsive target stability ; DLS ; dynamic light scattering ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase ; LDH ; lactate dehydrogenase ; MRI ; magnetic resonance imaging ; PBS ; phosphate buffer saline ; SDS ; sodium dodecyl sulfate
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：92
- 期：Complete
- 页码：29-38
- 全文大小：2761 K
文摘
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Oxidative stress causes glyceraldehyde-3-phospate dehydrogenase (GAPDH) aggregation.
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GAPDH aggregation is accompanied with cell death.
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Screening of substances preventing GAPDH aggregation was performed.
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Positive compounds revealed in screening specifically bind GAPDH molecule.
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GAPDH binders effectively protect cells and brain tissue against oxidative stress.
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