Genomic and lipidomic actions of nandrolone on detached rotator cuff muscle in sheep

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• 作者：Martin Flü ; ck ; PhD^a ; ¹ ; ^{mflueck@research.balgrist.ch} ; Severin Ruoss^a ; ¹ ; Christoph B. Mö ; hl^a ; Paola Valdivieso^a ; Mario C. Benn^b ; Brigitte von Rechenberg^b ; Endre Laczko^c ; Junmin Hu^c ; Karl Wieser^d ; Dominik C. Meyer^d ; Christian Gerber^d
• 关键词：Rotator cuff muscle ; Adipocyte ; Fat ; Gene expression ; Tenotomy ; Anabolic steroids ; Androgen receptor
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：165
• 期：part_PB
• 页码：382-395
• 全文大小：2624 K
• 卷排序：165

文摘

Early nandrolone application mitigates muscle-to-fat conversion with tendon release. Nandrolone down-regulates the muscle lipidome, independent of the transcriptome. Fatty, atrophied muscle looses responsiveness to nandrolone. The transcript response to nandrolone is down-regulated in detached muscle. Responsiveness to nandrolone is related to androgen receptor protein levels.