Preclinical study investigating the potential of low-dose-rate brachytherapy with ³²P stents for the prevention of restenosis of paranasal neo-ostia

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• 作者：Elmar Oestreicher¹ ; Harald Bartsch² ; Doris Mayr² ; Mario Schubert³ ; Barbara Weber¹ ; Peter Kneschaurek⁴ ; Walter Assmann³ ; Ronald Sroka⁵ ; ⁶ ; Christian Stephan Betz⁵ ; ⁷ ; ^{christian.betz@med.uni-muenchen.de}
• 关键词：Phosphorous-32 ; Low-dose brachytherapy ; Paranasal sinus ; Neo-ostium ; Restenosis
• 刊名：Brachytherapy
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：16
• 期：1
• 页码：207-214
• 全文大小：1466 K
• 卷排序：16

文摘

Ostial restenosis is a common cause of failures in paranasal sinus surgery. The aim of the current study was to investigate the use of low-dose-rate brachytherapy to prevent neo-ostial restenosis in an animal model.Methods and MaterialsIn 14 rabbits, maxillary neo-ostia were created and measured. One side each was stented with a regular silicone stent, the other side was either not stented (n = 7) or stented with a phosphorous-32 implanted stent depositing a low-dose radiation of 15 Gy (n = 7) within 1 week, after which all stents were removed. After a period of additional 12 weeks of recovery, the animals were sacrificed, the neo-ostia were again measured, and the areas and histopathologic changes compared in between the groups.ResultsAfter 15-Gy stenting, the mean ostial areas were even slightly enlarged by 5.1% compared to the area at stent removal, whereas a significant reduction in area, indicating a process of restenosis, by 56.1% or 54.0% was seen in the control groups with no stent and normal stent, respectively. Furthermore, no indication for adverse histopathologic radiation effects was seen in the 15-Gy group.ConclusionsLow-dose-rate brachytherapy with phosphorous-32 doped silicone stents showed promising results in the prevention of neo-ostium restenosis in this proof-of-concept study, indicating that further preclinical and clinical testing may be warranted.