Abnormal regional spontaneous neuronal activity associated with symptom severity in treatment-naive patients with obsessive-compulsive disorder revealed by resting-state functional MRI

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• 作者：Linlin Qiu^a ; ^b ; ¹ ; Xiangshuai Fu^c ; ^d ; ¹ ; Shuai Wang^c ; ^d ; Qunfeng Tang^e ; Xingui Chen^b ; Lin Cheng^f ; Fuquan Zhang^c ; ^d ; Zhenhe Zhou^c ; ^d ; Lin Tian^c ; ^d ; ^{tianz@njmu.edu.cn}
• 关键词：Obsessive-compulsive disorder ; Resting-state ; Functional magnetic resonance imaging (fMRI) ; Fractional amplitude of low-frequency fluctuation (fALFF) ; Spontaneous brain activity
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：640
• 期：Complete
• 页码：99-104
• 全文大小：982 K
• 卷排序：640

文摘

Decreased fALFF in thalamus was observed in treatment-naive OCD patients. Decreased fALFF in brain areas outside the CSTC circuits were also found. Decreased fALFF associated with symptom severity in treatment-naive OCD patients. Brain areas outside the CSTC circuits may play a role in the pathophysiology of OCD.