Valproic acid and ASK1 deficiency ameliorate optic neuritis and neurodegeneration in an animal model of multiple sclerosis

详细信息    查看全文

• 作者：Yuriko Azuchi^a ; ^b ; Atsuko Kimura^a ; Xiaoli Guo^a ; Goichi Akiyama^a ; Takahiko Noro^a ; Chikako Harada^a ; Atsuko Nishigaki^b ; Kazuhiko Namekata^a ; ^b ; ^{namekata-kz@igakuken.or.jp} ; Takayuki Harada^a
• 关键词：Valproic acid ; ASK1 ; Optic neuritis ; EAE ; Neuroprotection
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：3 February 2017
• 年：2017
• 卷：639
• 期：Complete
• 页码：82-87
• 全文大小：2469 K
• 卷排序：639

文摘

We examine the effects of VPA on optic neuritis in EAE mice. VPA suppresses demyelination in the optic nerve and protects retinal neurons. VPA shows enhanced effects on retinal protection in ASK1-deficient EAE mice. VPA and ASK1 inhibition may be useful for treatment of optic neuritis and MS.