Mechanisms of FGF gradient formation during embryogenesis

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• 作者：Revathi Balasubramanianp>ap>p> ; p>p>bp> ; Xin Zhangp>ap>p> ; p>p>bp>p> ; p>p>xz2369@columbia.edu" class="auth_mail" title="E-mail the corresponding authorp>
• 关键词：Heparan sulfate proteoglycans ; Morphogen ; Fibroblast growth factors
• 刊名：Seminars in Cell & Developmental Biology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：53
• 期：Complete
• 页码：94-100
• 全文大小：1401 K

文摘

Fibroblast growth factors (FGFs) have long been attributed to influence morphogenesis in embryonic development. Signaling by FGF morphogen encodes positional identity of tissues by creating a concentration gradient over the developing embryo. Various mechanisms that influence the development of such gradient have been elucidated in the recent past. These mechanisms of FGF gradient formation present either as an extracellular control over FGF ligand diffusion or as a subcellular control of FGF propagation and signaling. In this review, we describe our current understanding of FGF as a morphogen, the extracellular control of FGF gradient formation by heparan sulfate proteoglycans (HSPGs) and mechanisms of intracellular regulation of FGF signaling that influence gradient formation.