Preparation, characterization and toxicological investigation of copper loaded chitosan nanoparticles in human embryonic kidney HEK-293 cells
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- 作者：Divya Aroraa ; b ; 1 ; Vandna Dhanwalc ; 1 ; Debasis Nayaka ; c ; Ankit Sanejaa ; b ; Hina Aminc ; Reyaz ur Rasoola ; c ; Prem Narayan Guptaa ; b ; Anindya Goswamia ; c ; agoswami@iiim.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chitosan ; CuCSNPs ; Cytotoxicity ; ROS ; Caspase cleavage
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：61
- 期：Complete
- 页码：227-234
- 全文大小：1208 K
文摘
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Subtoxic levels of CuCSNPs induce apoptosis in HEK-293 cells.
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CuCSNPs mediate toxicity via nuclear cleavage and ROS generation.
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CuCSNPs favor caspase activation and PARP cleavage to induce cell death.