NDRG2 overexpression suppresses hepatoma cells survival during metabolic stress through disturbing the activation of fatty acid oxidation

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• 作者：Tao Pan^a ; ^b ; ¹ ; Mei Zhang^a ; ¹ ; Fang Zhang^c ; Guang Yan^a ; Yi Ru^a ; Qinhao Wang^a ; Yao Zhang^a ; Xuehui Wei^a ; Xinyuan Xu^a ; Lan Shen^a ; Jian Zhang^a ; Kaichun Wu^d ; Libo Yao^a ; ^{bioyao@fmmu.edu.cn} ; Xia Li^a ; ^{lixia@fmmu.edu.cn}
• 关键词：NDRG2 ; Fatty acid oxidation ; Metabolic stress ; Cell survival ; Hepatocellular carcinoma
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：483
• 期：2
• 页码：860-866
• 全文大小：1295 K
• 卷排序：483

文摘

NDRG2 overexpression reduces the tolerance of hepatoma cells to glucose limitation. NDRG2 overexpression aggravates energy imbalance and oxidative stress under glucose deprivation. NDRG2 overexpression disturbs the activation of FAO in hepatoma cells under glucose limitation. NDRG2 overexpression inhibits the activation of AMPK/ACC pathway in hepatoma cells during glucose starvation.