Photophysical characterization of anticancer drug valrubicin in rHDL nanoparticles and its use as an imaging agent
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- 作者：Sunil Shaha ; sunilajit.shah@live.unthsc.edu" class="auth_mail" title="E-mail the corresponding author ; Rahul Chiba ; Sangram Rautb ; Jaclyn Bermudezc ; Nirupama Sabnisd ; Divya Duggala ; Joseph D. Kimballb ; Andras G. Lackod ; Zygmunt Gryczynskia ; b ; Ignacy Gryczynskia ; ignacy.gryczynski@unthsc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Valrubicin ; rHDL nanoparticles ; Fluorescence spectroscopy ; Cancer ; Confocal imaging
- 刊名：Journal of Photochemistry and Photobiology B: Biology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：155
- 期：Complete
- 页码：60-65
- 全文大小：818 K
文摘
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Anti-cancer drug valrubicin has the potential to be a good theranostic agent.
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rHDL nanoparticles effectively shield hydrophobic valrubicin.
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Use of rHDL nanoparticles can reduce toxicity and improve diagnostic time.
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rHDl and free valrubicin have intrinsic fluorescence that can be used for imaging.
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Compared to valrubicin, rHDL nanoparticles have longer lifetime and quantum yield.