Changes in glucose-elicited blood metabolite responses following weight loss and long term weight maintenance in obese individuals with impaired glucose tolerance
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- 作者：Nina Geidenstama ; nina.geidenstam@med.lu.se" class="auth_mail" title="E-mail the corresponding author ; Anders P.H. Danielssona ; Peter Spé ; gelb ; Martin Ridderstrå ; lea ; c
- 关键词：Metabolomics ; Metabolite profiling ; Impaired glucose tolerance ; Amino acids ; Fatty acids
- 刊名：Diabetes Research and Clinical Practice
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：113
- 期：Complete
- 页码：187-197
- 全文大小：1392 K
文摘
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The metabolic response to a glucose load was analyzed before and after weight loss and after weight maintenance.
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Changes in metabolite patterns occurred differentially during weight loss and weight maintenance.
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Hepatic insulin sensitivity and suppression of aromatic amino acids improved with weight loss.
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Enhanced suppression of aromatic amino acids was associated with decreased insulinogenic index.
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Glucose tolerance and the majority of metabolite responses improved during weight maintenance.