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Kinetic investigation of human 5-lipoxygenase with arachidonic acid
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文摘

Kinetic isotope effect for human 5-lipoxygenase is reported.

Hydrogen abstraction is the rate-liming step for human 5-lipoxygenase.

Change in regioselectivity is observed upon deuteration at C-7 of arachidonic acid.

The viscosity experiments influence the Hkcat more than Dkcat and not the overall kcat/KM for AA and 7,7-d2-AA respectively.

Enzyme–substrate dynamics is proposed to affect the catalysis.

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