ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth
详细信息 查看全文
- 作者：Boyko S. Atanassov1 ; 2 ; batanass@mdanderson.org" class="auth_mail" title="E-mail the corresponding author ; Ryan D. Mohan3 ; Xianjiang Lan1 ; 2 ; 5 ; Xianghong Kuang1 ; 2 ; Yue Lu1 ; 2 ; Kevin Lin1 ; 2 ; Elizabeth McIvor1 ; 2 ; Wenqian Li1 ; 2 ; 5 ; Ying Zhang4 ; Laurence Florens4 ; Stephanie D. Byrum6 ; Samuel G. Mackintosh6 ; Tammy Calhoun-Davis1 ; 2 ; Evangelia Koutelou1 ; 2 ; Li Wang1 ; 2 ; Dean G. Tang1 ; 2 ; Alan J. Tackett6 ; Michael P. Washburn4 ; 7 ; Jerry L. Workman4 ; Sharon Y.R. Dent1 ; 2 ; 5 ; sroth@mdanderson.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：19 May 2016
- 年：2016
- 卷：62
- 期：4
- 页码：558-571
- 全文大小：4215 K
文摘
- •
USP22 competes with USP27X and USP51 for activation by ATXN7L3 and ENY2
- •
USP27X and USP51 function independently of SAGA
- •
ATXN7L3 and ENY2 availability is tightly regulated in cells
- •
USP51 and USP27x ablation impairs cell proliferation and tumor progression