Cholinergic modulation of auditory P3 event-related potentials as indexed by CHRNA4 and CHRNA7 genotype variation in healthy volunteers
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- 作者：Molly Hydea ; Molly.Hyde@TheRoyal.ca" class="auth_mail" title="E-mail the corresponding author ; Joë ; lle Choueirya ; Joelle.Choueiry@TheRoyal.ca" class="auth_mail" title="E-mail the corresponding author ; Dylan Smitha ; Dylan.m.smith@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sara de la Salleb ; Sara.delaSalle@TheRoyal.ca" class="auth_mail" title="E-mail the corresponding author ; Renee Nelsona ; Renee.Nelson@TheRoyal.ca" class="auth_mail" title="E-mail the corresponding author ; Danielle Impeyb ; Danielle.Impey@TheRoyal.ca" class="auth_mail" title="E-mail the corresponding author ; Ashley Baddeleyc ; Ashley.Baddeley@TheRoyal.ca" class="auth_mail" title="E-mail the corresponding author ; Robert Aidelbaumd ; Robert.Aidelbaum@TheRoyal.ca" class="auth_mail" title="E-mail the corresponding author ; Anne Millara ; adzobeen@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Verner Knotta ; b ; c ; d ; Verner.Knott@TheRoyal.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alpha 7 nicotinic acetylcholine receptor (α7 nAChR) ; Alpha 4 nicotinic acetylcholine receptor (α4 nAChR) ; Choline transporter ; Attention ; P300 ; Schizophrenia
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：3 June 2016
- 年：2016
- 卷：623
- 期：Complete
- 页码：36-41
- 全文大小：600 K
文摘
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CHRNA4C/C homozygotes show lower involuntary (P3a) and voluntary (P3b) attention.
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CHRNA7C/C homozygotes show lower voluntary (P3b) attentional processing.
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Mutations at the SLC5A7 gene did not significantly affect attention.