RNCR3: A regulator of diabetes mellitus-related retinal microvascular dysfunction

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• 作者：Kun Shan^a ; ^b ; ^c ; ¹ ; Chao-Peng Li^d ; ¹ ; Chang Liu^a ; ^b ; ^c ; Xin Liu^a ; ^b ; Biao Yan^a ; ^b ; ^{biao.yan@fdeent.org}
• 关键词：Long noncoding RNA ; Diabetic retinopathy ; Microvascular abnormalities
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：777-783
• 全文大小：1416 K
• 卷排序：482

文摘

RNCR3 expression is significantly up-regulated upon high glucose stress. RNCR3 knockdown alleviates retinal vascular dysfunction in vivo. RNCR3 regulates retinal endothelial cell function in vitro. RNCR3 regulates retinal endothelial cell function via RNCR3/KLF2/miR-185-5p pathway.