Impact of coronary artery disease in elderly patients undergoing transcatheter aortic valve implantation: Insight from the Italian CoreValve Registry

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• 作者：Gian Paolo Ussia ; Marco Barbanti ; Antonio Colombo ; Giuseppe Tarantini ; Anna Sonia Petronio ; Federica Ettori ; Angelo Ramondo ; Gennaro Santoro ; Silvio Klugmann ; Francesco Bedogni ; David Antoniucci ; Francesco Maisano ; Antonio Marzocchi ; Arnaldo Poli ; Marco De Carlo ; Claudia Fiorina ; Federico De Marco ; Massimo Napodano ; Roberto Violini ; Aless ; ro Santo Bortone ; et al.
• 关键词：Aortic stenosis ; TAVI ; Atherosclerosis ; Coronary artery disease
• 刊名：International Journal of Cardiology
• 出版年：2013
• 出版时间：10 August, 2013
• 年：2013
• 卷：167
• 期：3
• 页码：943-950
• 全文大小：704 K

文摘

Background

Coronary artery disease (CAD) commonly coexists with degenerative aortic stenosis. The impact of CAD in patients undergoing transcatheter aortic valve implantation (TAVI) raises concerns due to the lack of comprehensive and consistent data on this topic. We sought to evaluate the impact of CAD on clinical outcomes in patients undergoing TAVI.

Methods

Consecutive patients(N = 663) who underwent TAVI with the 18-French CoreValve ReValving System (CRS) (Medtronic Inc, MN USA) from June 2007 through December 2009 at 14 institutions across Italy were included in this prospective web-based registry. Four patients were excluded from the analysis due to failure to successfully release the prosthesis inside the native aortic valve. Previous percutaneous or surgical myocardial revascularizations were used to identify the existence of concomitant CAD (N = 251; 38 % ). The primary endpoint was the incidence of Major Adverse Cerebrovascular and Cardiac Events (MACCE) and all-cause death in CAD and no-CAD groups.

Results

Patients with CAD were no more likely to develop MACCE within 12-months of the procedure than those who did not (CAD group vs no-CAD group, 15.7 % vs 18.3 % ; adjusted hazard ratio [HR] 0.76; 95 % confidence interval [CI] 0.42 to 1.36; p = 0.353). The 12-month mortality was 14.5 % and 15.9 % in CAD group and no-CAD group, respectively (adjusted HR 0.74; 95 % CI 0.40 to 1.36; p = 0.331).

Conclusions

Coexisting CAD does not impact procedural outcomes and mid-term incidence of MACCE and survival in elderly patients undergoing TAVI with CRS prosthesis.