Targeting membrane trafficking in infection prophylaxis: dynamin inhibitors

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• 作者：Callista B. Harper¹ ; Michel R. Popoff² ; Adam McCluskey³ ; Phillip J. Robinson⁴ ; ^{probinson@cmri.org.au} ; Fré ; dé ; ric A. Meunier¹ ; ^{f.meunier@uq.edu.au}
• 关键词：dynamin ; pathogens ; neurotoxins ; prophylaxis ; trafficking ; endocytosis
• 刊名：Trends in Cell Biology
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：23
• 期：2
• 页码：90-101
• 全文大小：750 K

文摘

Many pathogens hijack existing endocytic trafficking pathways to exert toxic effects in cells. Dynamin controls various steps of the intoxication process used by numerous pathogenic bacteria, viruses, and toxins. Targeting dynamin with pharmaceutical compounds may therefore have prophylactic potential. Here we review the growing number of pathogens requiring dynamin-dependent trafficking to intoxicate cells, outline the mode of internalization that leads to their pathogenicity, and highlight the protective effect of pharmacological and genetic approaches targeting dynamin function. We also assess the methodologies used to investigate the role of dynamin in the intoxication process and discuss the validity and potential pitfalls of using dynamin inhibitors (DIs) as therapeutics.