Lipoic acid improves neuronal insulin signalling and rescues cognitive function regulating VGlut1 expression in high-fat-fed rats: Implications for Alzheimer's disease
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- 作者：Manuel Rodriguez-Perdigona ; 1 ; Maite Solasa ; b ; 1 ; Maria Jesú ; s Moreno-Aliagab ; c ; d ; Maria Javier Ramireza ; b ; mariaja@unav.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：High-fat-diet ; Insulin ; Ketone bodies ; Cognitive deficits ; VGlut1
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1862
- 期：4
- 页码：511-517
- 全文大小：664 K
文摘
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HFD rats showed memory impairments.
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HFD induced peripheral insulin resistance and increases in 3-β-OHB.
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HFD induced alterations in central insulin signalling.
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VGlut1 levels were significantly decreased in the hippocampus of HFD rats.
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All effects induced by HFD were counteracted by LA administration.