• 作者：E. Garcí ; a-Cruz^a ; ^{edu_garcia_cruz@yahoo.com} ; R. Casta&ntilde ; eda-Argá ; iz^a ; A. Carrió ; n^a ; J. Alcover^a ; A. Sallent^b ; A. Leibar-Tamayo^c ; J. Romero-Otero^d ; A. Alcaraz^a ; en nombre de la Red Espa&ntilde ; ola de Investigació ; n en Salud del Hombre (REISHO)
• 关键词：Testosterona ; Cá ; ncer de pró ; stata ; Prostatectomí ; a radical ; Recidiva bioquí ; mica
• 刊名：Actas Urol¨®gicas Espa?olas
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：37
• 期：5
• 页码：280-285
• 全文大小：1406 K

Objective

There is controversial evidence regarding preoperative testosterone (T) levels related to poor prognosis factors after radical prostatectomy (RP). The aim of this manuscript is to determine the relationship between preoperative T levels and final pathologic report together to biochemical recurrence after RP.

Materials and methods

We prospectively analysed 143 patients submitted to RP from February 2008 to June 2010 in our centre. Pretreatment T and sex hormone-binding globulin levels were determined as part of our clinical protocol. Free calculated (fT) and bioavailable (bioT) T were calculated using Vermeulen's formula. Low T levels were defined as 346 ng/dL or less. A comparative analysis with variables pTNM, positive margins, tumour burden, Gleason score, multifocality and biochemical recurrence (using both PSA > 0.4 ng/dL and PSA > 0.2 ng/dL as cut-off values) was performed, according to preoperative levels of T.

Results

Variables Gleason score, rate and number of positive margins, tumour burden, tumour multifocality, time to biochemical recurrence and pathological stage were not related to preoperative hormonal levels. Preoperative T < 346 ng/dL was not found to be related to PSA recurrence (PSA > 0,4 ng/dL log-rank, P = .512), although a trend was observed when PSA > 0,2 ng/dL (log-rank, P = .097).

Conclusion

Preoperative T levels were not related to final pathological report or to biochemical recurrence.