New preparation of difluoroiodomethylsulfanylbenzenes and their radical addition to unsaturated compounds initiated by sodium dithionite

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• 作者：Xueyan Yang ; Xiang Fang ; Xianjin Yang ; Min Zhao ; Yizheng Han ; Yongjia Shen ; Fanhong Wu
• 关键词：Difluoroiodomethylsulfanylbenzene ; Difluoromethylene ; γ ; -Butyrolactone ; Addition ; Tetrahydrofuran derivatives
• 刊名：Tetrahedron
• 出版年：2008
• 出版时间：25 February 2008
• 年：2008
• 卷：64
• 期：9
• 页码：2259-2269
• 全文大小：450 K

文摘

Difluoroiodomethylsulfanylbenzene (rong>3arong>) and 1-chloro-4-difluoroiodomethylsulfanylbenzene (rong>3brong>) are novel and efficient difluoromethylating reagents via the reaction with unsaturated compounds, such as alkenes, ethynylbenzene, pent-4-en-1-ols, and pent-4-enoic acids initiated by Na₂S₂O₄, to afford the corresponding adducts, tetrahydrofuran derivatives, and γ-butyrolactones containing difluoromethylene group in moderate to good yields.