Astragaloside IV improves the isoproterenol-induced vascular dysfunction via attenuating eNOS uncoupling-mediated oxidative stress and inhibiting ROS-NF-κB pathways
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- 作者：Chonghua Xu1 ; Futian Tang1 ; Meili Lu ; Jing Yang ; Ronghui Han ; Meng Mei ; Jin Hu ; Mingsheng Zhou ; Hongxin Wang ; hongxinwang@lnmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Astragaloside IV ; Isoproterenol ; eNOS uncoupling ; NF-κB ; Tetrahydrobiopterin
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：33
- 期：Complete
- 页码：119-127
- 全文大小：909 K
文摘
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Astragaloside IV (AsIV) improved the vascular dysfunction of the aorta induced by Iso.
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AsIV inhibited eNOS uncoupling-mediated oxidative stress in aorta induced by Iso.
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AsIV regulated the aortic protein expressions of NF-κB p65 and its inhibitor IκB-α.
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AsIV downregulated aortic genes expression of proinflammatory cytokines.
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