Stochastic modeling of systems mapping in pharmacogenomics

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• 作者：Zuoheng Wang ; Jiangtao Luo ; Guifang Fu ; Zhong Wang ; Rongling Wu
• 关键词：Stochastic differential equation ; PK ; PD ; Statistical model ; Genetic architecture ; Drug response
• 刊名：Advanced Drug Delivery Reviews
• 出版年：2013
• 出版时间：30 June, 2013
• 年：2013
• 卷：65
• 期：7
• 页码：912-917
• 全文大小：423 K

文摘

As a basis of personalized medicine, pharmacogenetics and pharmacogenomics that aim to study the genetic architecture of drug response critically rely on dynamic modeling of how a drug is absorbed and transported to target tissues where the drug interacts with body molecules to produce drug effects. Systems mapping provides a general framework for integrating systems pharmacology and pharmacogenomics through robust ordinary differential equations. In this chapter, we extend systems mapping to more complex and more heterogeneous structure of drug response by implementing stochastic differential equations (SDE). We argue that SDE-implemented systems mapping provides a computational tool for pharmacogenetic or pharmacogenomic research towards personalized medicine.