- 作者：Fernando Guerrero-Romero ; MD ; PhD1 ; 2 ; Martha Rodrí ; guez-Morá ; n ; MD ; MSc ; PhD2 ; rodriguez.moran.martha@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Gabriela Herná ; ndez-Ronquillo ; MD1 ; Rita Gó ; mez-Dí ; az ; MSc3 ; 4 ; Marí ; a L. Pizano-Zarate ; MD ; MSc3 ; 5 ; Niels H. Wacher ; MD ; MSc6 ; Rafael Mondragó ; n-Gonzá ; lez ; MD6 ; Luis E. Simental-Mendia ; MD ; MSc ; PhD1 ; 2 ; on behalf of the Network of Childhood Obesity of the Mexican Social Security Institute&lowast ; Ana Marí ; a Salinas Martí ; nez ; MD ; PhD ; Andrea Socorro Á ; lvarez Villaseñ ; or ; MD ; Anel Gó ; mez Garcí ; a ; MD ; PhD ; Antonio Pineda Carranza ; MD ; Brian Gonzá ; lez Pé ; rez ; MD ; Carolina Elizabeth Medina Escobedo ; MD ; Cecilia Colunga Rodrí ; guez ; MD ; PhD ; Celsa Ló ; pez Campos ; MD ; MSc ; Cruz Mó ; nica Ló ; pez Morales ; MD ; Eduardo Almeida Gutié ; rrez ; MD ; MSc ; Eulalia Piedad Garrido Magañ ; a ; MD ; Flor Araceli Nava Ayala ; MD ; Francisco Gonzá ; lez Salazar ; MD ; Gabriela Borrayo Sá ; nchez ; MD ; PhD ; Gabriela Escudero Lourdes ; MD ; Gloria Patricia Sosa Bustamante ; MD ; Guadalupe Ruí ; z Vivanco ; MSc ; PhD ; Haydé ; Rosas Vargas ; MD ; Hé ; ctor Rafael Sá ; nchez Nuncio ; MD ; MSc ; Irma Isordia Salas ; MD ; PhD ; Jesus Nares Cisneros ; MD ; José ; de Jesú ; s Peralta Romero ; MD ; MSc ; PhD ; José ; Ramó ; n Paniagua Sierra ; MD ; MSc ; PhD ; Laura Hermila de la Garza ; MD ; Ma. Guadalupe Ruí ; z Charles ; MD ; Marco Antonio Leó ; n Mazó ; n ; MD ; Mardia Ló ; pez Alarcó ; n ; MD ; MSc ; Marí ; a de Socorro Romero Figueroa ; MD ; Marí ; a Elena Haro Acosta ; MD ; Maria Elena Y. Furuya Meguro ; MD ; PhD ; Marí ; a Eugenia Galvá ; n Plata ; MD ; Marí ; a Valeria Jimé ; nez Baé ; z ; MD ; Martha I. Dá ; vila Rodrí ; guez ; MD ; Miguel Angel Villasis Keever ; MD ; MSc ; Miguel Cruz Ló ; pez ; PhD ; Mirna Aurea Huerta Orea ; MD ; Norma Alicia Sá ; nchez Herná ; ndez ; MD ; Ricardo Jorge Herná ; ndez Herrera ; MD ; Ricardo Pé ; rez Fuentes ; MSc ; PhD ; Ricardo Salas Flores ; MD ; Rosa Ortega Corté ; s ; MD ; Sonia Lazcano ; MD
- 关键词：BMI ; Body mass index ; BP ; Blood pressure ; DBP ; Diastolic blood pressure ; HBP ; High blood pressure ; HDL-C ; High-density lipoprotein cholesterol ; preHTN ; Prehypertension ; SBP ; Systolic blood pressure ; WC ; Waist circumference
- 刊名：The Journal of Pediatrics
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：168
- 期：Complete
- 页码：93-98.e1
- 全文大小：544 K
Study design
A total of 3954 apparently healthy Mexican children were enrolled in a cross-sectional study. Exclusion criteria were type 2 diabetes; hepatic, renal, or endocrine disease; impaired fasting glucose; chronic diarrhea; and intake of vitamins or magnesium supplements in the previous 6 months. preHTN was defined by systolic and/or diastolic blood pressure ≥90th to <95th percentile and hypertension by systolic and/or diastolic blood pressure ≥95th percentile, according to age, sex, and height percentile. Hypomagnesemia was defined by serum magnesium concentration <1.8 mg/dL (<0.74 mmol/L). To control for potential sources of bias related to age, participants were allocated into 2 groups, aged 6-10 years and 11-15 years.
Results
The prevalence of preHTN and hypertension was 12.2% and 6.4%, respectively, in children aged 6-10 years and 13.9% and 10.6% in those aged 11-15 years. Hypomagnesemia was identified in 59 children with preHTN (27.3%) and 52 (45.6%) with hypertension in the 6-10 year age group, and in 115 children with preHTN (36.0%) and 109 (49.6%) with hypertension in the 11-15 year age group. Adjusted multiple logistic regression analysis showed that in children in both age groups, hypomagnesemia was associated with both preHTN (6-10 years: OR, 2.18, P < .0005; 11-15 years: OR, 1.38, P = .018) and hypertension (6-10 years: OR, 4.87, P < .0005; 11-15 years: OR, 1.83, P = .0002).
Conclusion
Our results indicate that serum magnesium level <1.8 mg/dL is significantly associated with preHTN and hypertension in apparently healthy children.