- 作者：Jesú ; s K. Yamamoto-Furushoa ; kazuofurusho@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Rosalinda Posadas-Sá ; nchezb ; rossy_posadas_s@yahoo.it" class="auth_mail" title="E-mail the corresponding author ; Edith Alvarez-Leó ; nc ; edalvaleo@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Gilberto Vargas-Alarcó ; nc ; gvargas63@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：APCs ; antigen presenting cells ; CD ; Crohns disease ; EBI3 ; Epstein-Barr virus-induced gene 3 ; EIMs ; extra-intestinal manifestations ; IBD ; inflammatory bowel disease ; IFN ; interferon ; LD ; linkage disequilibrium ; PCR ; polymerase chain reaction ; SNP ; single nucleotide polymorphism ; UC ; ulcerative colitis
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：172
- 期：Complete
- 页码：79-83
- 全文大小：515 K
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Four polymorphisms of IL-27p28 gene (rs181206, rs26528, rs17855750, and rs40837) and three of the Epstein-Barr virus-induced gene 3 (EBI3) (rs428253, rs4740, and rs4905) were genotyped in 375 Mexican patients with UC and 1599 Mexican Mestizo healthy unrelated individuals.
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Under recessive model, the IL-27p28 rs17855750 polymorphism was associated with decreased risk of developing UC (OR = 0.27, 95% CI: 0.06–1.13, P = 0.031).
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Under recessive models, the EBI3 rs428253 (OR = 0.54, 95% CI: 0.29–0.99, P = 0.035), rs4740 (OR = 0.60, 95% CI: 0.36–1.01, P = 0.046) and rs4905 (OR = 0.59, 95% CI: 0.35–1.01, P = 0.043) were associated with decreased risk of developing UC.
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IL-27 polymorphisms might play a protective role for the development of UC in the Mexican population.