Biphasic Dependence of Glioma Survival and Cell Migration on CD44 Expression Level

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• 作者：Rebecca L. Klank¹ ; ⁷ ; Stacy A. Decker Grunke² ; ⁷ ; Benjamin L. Bangasser¹ ; Colleen L. Forster³ ; Matthew A. Price³ ; Thomas J. Odde¹ ; Karen S. SantaCruz³ ; Steven S. Rosenfeld⁴ ; Peter Canoll⁵ ; Eva A. Turley⁶ ; James B. McCarthy³ ; John R. Ohlfest² ; ⁸ ; David J. Odde¹ ; ⁹ ; ^{oddex002@umn.edu}
• 关键词：CD44 ; glioma ; biphasic migration ; biphasic survival
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：18
• 期：1
• 页码：23-31
• 全文大小：2456 K
• 卷排序：18

文摘

Glioblastoma survival in mice and humans depends biphasically on CD44 levels Intermediate CD44 levels are linked to high cell migration rates and poor survival High levels of CD44 correlate with better patient outcomes Net proliferation rates are independent of CD44, consistent with a biophysical theory