A Canine Model of Chronic Graft-versus-Host Disease

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• 作者：Scott S. Graves¹ ; ^{sgraves@fredhutch.org} ; Andrew Rezvani¹ ; George Sale¹ ; ² ; Diane Stone¹ ; Maura Parker¹ ; Steven Rosinski¹ ; Michele Spector¹ ; Bruce Swearingen¹ ; Leslie Kean³ ; Rainer Storb¹ ; ⁴
• 关键词：Chronic graft-versus-host disease ; Canine model
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：23
• 期：3
• 页码：420-427
• 全文大小：1848 K
• 卷排序：23

文摘

We have developed a protocol that consistently produces de novo chronic graft-versus-host disease in the clinically relevant hematopoietic cell transplantation canine model We have shown that the esophagus is targeted in the canine chronic graft-versus-host disease in a manner similar to that of the human We have shown that the outbred canine model possesses a broad spectrum of manifestations of chronic graft-versus-host disease that are typically seen clinically Initial mechanistic studies revealed that levels of select chemokines and cytokines are similarly affected in the canine as in the clinical setting